Kerber, playing in the tournament under number 11 in the final match on Saturday beat Williams, number 25, 6-3 and 6-3.
For 30-year-old Kerber, this is her third victory in the Grand Slam tournament in singles, as she won the Australian and US Opens in 2016.
Tennis - Wimbledon - All England Lawn Tennis and Croquet Club, London, Britain - July 14, 2018. Serena Williams of the U.S. reacts during the women's singles final against Germany's Angelique Kerber
© REUTERS / Toby Melville
Serena Williams fought back, trying to cut the deficit, making the score 3-2 to her advantage.
But her efforts were not enough to change the course of the game, as the tenacious Kerber regained her composure to secure a 6-3 win in the opening set.
Former champion Serena Williams is a sevenfold champion of Wimbledon.