The fight held at Wembley Stadium in London ended in the seventh round.
Povetkin suffered his second defeat having 34 victories with 24 knockouts. Joshua took his 22nd victory in his unbeaten record with 21 knockouts.
Hours before the fight, Anthony Joshua said that this bout definitely won’t be a cakewalk, saying that he had to be prepared "to go through hell and back."
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Joshua boasted a perfect record of 21 victories, 20 of them by knockout, and no defeats, while Povetkin previously won 34 fights, 24 of them by knockout.