"We achieved the largest cocaine seizure of the year aboard a 'go fast' boat, more than 2.4 tonnes [metric tons]," Molano wrote on Twitter on Sunday, releasing some video footage of the operation.
According to the video, five people were captured during the operation.
The defense minister said that the seizure prevented the "Gulf Clan" (Clan del Golfo) from getting $80 million.
Last year, Colombia had 143,000 hectares of illegal coca plantations and the country remains the world’s top producer of coca, according to the United Nations.