Multiple blasts could be heard inside the US military base in the At-Tanf area, located in Homs Province, near the Iraqi border, Syrian state TV reported on Sunday. At the same time, the broadcaster Al-Arabiya reported that several stikes targeting the base were carried out in the area.
The American military has not commented on the reports so far.
Last month, the NYT reported that the base was targeted by "suicide drones" in October, alleging that the attack was coordinated by Tehran.
Members of 5th Special Forces Group (A) conducting 50. Cal Weapons training during counter ISIS operations at Al Tanf Garrison in southern Syria on November 22, 2017.
The desert base, located along the M2 Baghdad-Damascus highway, has been held by American forces since 2016. At the time, it was used to train US-backed opposition forces, fighting against the government of President Assad.
American forces are operating on Syrian territory without the consent or authorisation of the United Nations. Damascus has repeatedly underscored that the presence of US troops in Syria is illegal because they were never invited for deployment.