"He will talk about what to expect as we head into the winter months, and detail additional steps that we will be taking", Psaki said during a press briefing on Monday.
Biden has said that so-called fully vaccinated individuals who have also received a booster dose will likely have mild or asymptomatic Omicron cases, Psaki said.
"We continue to see, and our health experts assess that you are 14 times more likely to die of COVID if you have not been vaccinated versus vaccinated. Importantly, he'll restate we're prepared and that fully vaccinated individuals have the tools to protect themselves with a booster shot and masking", she added.
Asked about the possibility of the Biden administration imposing new lockdowns, Psaki said Biden's speech will outline to the American people the benefits of being vaccinated, the upcoming steps to increase testing, and the risks posed to unvaccinated individuals.