"But the one we're not talking about enough is even more consequential: that the Iranians break out and acquire nuclear capability", Graham said, calling it "the game-changer of all game-changers".
"I guarantee you the Jewish people can't live that way. One Holocaust was enough. There will be war. Why can't Iran have nuclear weapons? Because Israelis say, 'Never again'", Graham said, invoking a slogan used to denounce the Nazis' mass Judeocide in the 1930s and 40s.
Iran has denied it has a nuclear weapons programme, which the International Atomic Energy Agency (IAEA) regulatory group has verified has not existed for nearly two decades. In 2010, Ayatollah Ali Khamenei, Iran's top political and religious leader, issued a legal ruling finding the use of nuclear weapons and all weapons of mass destruction to be against the teachings of Islam.
Iran has backed off the agreements it made in the JCPOA about keeping only small amounts of low-purity uranium-235, slowly increasing the quality and quantity of refined uranium it produces as a way of pressuring Washington to return to the deal. They have pledged not to produce uranium of more than 60% U-235, which nuclear weapons designers say is insufficient to construct a nuclear weapon with, and even Israeli military intelligence has conceded in recent months that there are no signs Iran is approaching a so-called "breakout" moment, when nuclear weapon construction would accelerate quickly.
Graham has also been strongly critical, claiming the Iranians were "playing President Biden like a fiddle" and that a war between Israel and Iran has become more likely than ever.