US media reported that at least 50 illegal immigrants died after they were abandoned inside a tractor-trailer near the city of San Antonio under sweltering heat.
"This incident underscores the need to go after the multi-billion dollar criminal smuggling industry preying on migrants and leading to far too many innocent deaths," Biden said.
The US president also said the US government will intensify its efforts in the months ahead to crack down on human smuggling.
Numerous critics of the Biden administration have pointed out that the number of illegal immigrants entering the United States since Biden assumed office in January 2021 has reached record high and well exceeds 2 million.