The rocket was launched from the Baikonur Cosmodrome at 03:20 a.m. Moscow time (0020 GMT) on October 26.
Docking with the station is scheduled for 5:50 a.m. Moscow time (0250 GMT) on October 28.
The Progress MS-21 will deliver more than 2.5 tonnes of cargoes to the ISS - fuel for the station, drinking water, nitrogen to maintain the atmosphere on the ISS, resource equipment for the Russian segment systems, personal protective equipment, medical control and sanitary and hygienic equipment, new clothing, diets and fresh food, as well as other items.