"The IDF is striking numerous (12) Syrian and Iranian military targets in Syria, in response to Iranian aggression," IDF spokesman Jonathan Conricus said on Twitter.
Earlier in the day, an Israeli helicopter downed an Iranian drone after it crossed into the Israel-occupied Golan Heights and struck at what the Israeli military said were Iranian targets in Syria, prompting Syrian fire.
READ MORE: Syrian Air Defense Systems Repel Yet Another Israeli Attack — Reports
Syrian air defense systems opened fire on Israel that triggered air raid sirens. The Israeli military did not say if the attack had been successful. An army spokesperson told Sputnik that an Israeli Air Force jet came down in the country’s north.
"Early in the morning Israeli jets committed yet another act of aggression attacking one of the military bases in central Syria. Our anti-aircraft defense opened fire and hit several jets," the source was quoted as saying by the SANA news agency.
Following the incident, Israel Airports Authority (IAA) has closed the airspace over major part of Israel.
"The [Ben Gurion international] airport is operating in normal mode… The air space to the north of Shefayim [settlement] is closed for flights," the statement read.
During the incidents all flights were delayed for 15-20 minutes.
Earlier in the week, Syrian air defenses have responded to an Israeli attack near Damascus, according to to Syrian SANA state-run agency. Haaretz reported later, citing sources, that Israeli missiles had targeted a "research center", located north of Damascus.
Israel and Syria have never signed a peace treaty and have been repeatedly exchanging attacks in bordering areas.