The event, dubbed National Day of Action Against Gun Violence in Schools, was organized by a group of activists who said they are calling for higher quality of education in public schools.
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The demonstration marks the 19th anniversary of the Columbine High School massacre in the US state of Colorado, where two high school students shot and killed 13 people and injured 36 more.
Many of the participants in Friday’s protest are wearing orange shirts, hats and bandages, and hold placards that read "Enough"; "Arm teachers with pencils, not guns"; "No more silence, no more gun violence"; "Prayers can't stop bullets" and others.
Students in other cities across the United States have joined the protest, according to reports.
Earlier in the day, one person was injured in a shooting at a high school in Ocala, Florida, according to the Marion County Sheriff's Office. A suspect has been arrested.
The Second Amendment of the US Constitution guarantees the right of Americans to keep and bear arms.