On Saturday morning, Alfie's parents said via social media that their son had passed away after doctors withdrew his life support on Monday.
"I love my guy," the boy's father, Thomas Evans, wrote on Facebook.
Several courts, including the Court of Appeals of Great Britain, ruled that Alfie Evans could not be transferred to the Italian hospital to continue treatment, since scans of his brain had shown that almost all of it had been damaged and thus additional treatments would have not produced any results, according to the doctors.
Social media users took to Twitter to express their condolences to boy's parents and thank doctors for the work they had done, fighting for Alfie's life.
Some users, however, blamed the doctors for not allowing the toddler to be transferred to the Italy's hospital; though, according to medical examinations, he could not get better.