The accident took place in the Ribera d'Ebre county in the Tarragona province. Firefighters and medics were dispatched to the site of the crash, however, they failed to rescue the accident victims.
The aircraft was en route from the Portuguese city of Cascais to the city of Reus, located in Tarragona when it crashed.
The authorities have not yet determined the nationalities of the crash victims.
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The Civil Defense has followed the protocol and has activated in Alert the Special Plan for Aeronautical Emergencies in Catalonia, Aerocat, while the Reus Airport operates normally.