Universal media outlet reported that the death toll in the blast at a nightclub in the Venezuelan capital had risen to 21.
Earlier in the day, Venezuelan Interior Minister Nestor Reverol said that at least 17 people died in a brawl at a Caracas nightclub early on Saturday morning.
Earlier in the day, some 500 people were at the Los Cotorros club, when a tear gas device went off during a brawl between several people.
Eleven people have reportedly suffocated to death, including the man, who threw the grenade, while there was a stampede toward the exits. The Venezolana de Television broadcaster reported that eight victims were underage.
An investigation into the incident has been underway, with 7 people already being arrested, according to the interior minister.
"The government of the Bolivarian Republic of Venezuela, led by President Nicolas Maduro, deplores this unfortunate event. We send our condolences to the families," he said.
Other visitors of the club were delivered to nearby hospitals.
No further details have been immediately available.