"Four young Palestinian men were injured by bullets from the Israeli forces at the entrance to the Deir Abu Mash'al settlement [northwest of the city of Ramallah]," the statement said.
One of the injured is in serious condition, according to the ministry.
The latest surge of violence in Gaza erupted on Monday after a Hamas commander was killed in a covert Israeli operation. Since then, Gaza militants have fired at least 460 rockets at Israel, and Israeli forces have carried out airstrikes on 160 targets in Gaza.
READ MORE: At Least 40 Palestinians Injured in Gaza Border Clashes — Health Authority
At least seven Palestinians and one Israeli have died as a result of the renewed tensions. On Tuesday evening, the sides returned to a truce, completing the most intense fire exchange in the past four years.