The suspect is dead following a shooting incident involving a police officer, AL.com reports.
At the moment it is unclear how many people were injured at the Riverchase Galleria in Hoover, which is situated 10 miles from Birmingham, the state's largest city.
According to witnesses, there were two separate bursts of gunfire, which were thought to take place between JCPenny department store and Footaction shoe store near the shopping centre's food court.
The police presence on the scene has intensified as they attempt to clear the area.
Four people were injured, according to WBRC TV news. Hoover police have said that the situation is "under control".