"I think that nothing good has come out of the French-German union for Europe. I want to rebuild the Berlin-Rome axis to give EU a new impetus," Salvini told reporters.
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He said the European Union was in danger after being governed for decades by the same people.
The Italian official also noted that dialogue between Germany and Italy is crucial given "problems in France."
Salvini comments come after a step taken by French President Emmanuel Macron last year when he singled out Germany as his partner of choice for intense cooperation on reforming the soon-to-be 27-nation bloc. He has been on the defensive since protests against a rise in fuel taxes sparked weeks of protests at home.