At least six people were on board the helicopter and aircraft, which fell near the Rutor glacier in the Italian Alps, in the deep valley of La Thuile, a respresentative of local emergency service told Sputnik.
The tourist plane and the helicopter were flying at around 10,000ft at the time of the crash.
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A helicopter with Alpine Rescue staff and medics on board has rushed to the site of the incident.
The National Alpine and Speleological Rescue Corps said in a Tweet that a search-and-rescue effort is underway.