The Nacional media outlet reported that fire brigades had arrived on the scene without revealing additional details or the cause of the explosion.
La Guaira, the capital city of Venezuela's northern Vargas state and the nation's primary port, was founded in 1577 and has been the scene of several key naval battles during the late-20th-century forming of the oil-rich South American country.
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Last year, a powerful explosion at an LPG dispensing station belonging to the Venezuelan state-owned PDVSA energy company and located in the state of Miranda in the north of the country saw two killed and six others injured.