According to the Israeli military, the attack took place at the Ariel Junction.
One man was gravely wounded in a shooting at Ariel Junction in the West Bank, Haaretz reported. The attacker reportedly fled the scene.
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Another incident happened at Giti Junction, west of Ariel: two people were shot. They are considered to be in serious condition.
The Israel Defence Forces are pursuing the attacker, who is still at large, according to reports.
The situation between Israel and the Palestinian Authority remains tense over a series of attacks and incidents that have taken place in recent months.
For decades, Israel has been in conflict with the Palestinians, who have been seeking diplomatic recognition for their independent state on the territories of the West Bank, including East Jerusalem, which is partially occupied by Israel, and the Gaza Strip.