The column of ash erupted from the volcano late on Wednesday, after which it continued spewing gases to an altitude of 800 metres (2,624.5 feet). The authorities have warned local residents against approaching the volcano.
Popocatepetl is located 70 kilometres from Mexico City and is one of the country's largest volcanos.
Its activity has increased following a recent environmental emergency which occurred in the capital due to high air pollution levels in the area.