"Nine people have been killed and at least twenty others injured this afternoon following a multiple-vehicle collision on the N3 near the Barry Marais Offramp in Vosloorus," ER24 said in a statement.
Paramedics arrived at the scene at 1:10 p.m. local time (11:10 GMT) to find at least four cars and four trucks scattered along the road.
READ MORE: Lost City DISCOVERED Next to Johannesburg in South Africa (VIDEO)
Numerous people were lying on the road and several others were found inside the upturned vehicles. Dozens were attended on the scene. Their injuries range from minor to critical, ER24 said.
The details surrounding the collision were not immediately known, the health authority said. Local authorities are conducting an investigation.