The airstrike reportedly targeted al-Zaytoun, an area that was also hit by the Israeli Air Force the previous night, again following a rocket attack in southern Israel earlier that day, Sputnik reported.
Observers recorded the roar of Israeli jet aircraft over the city and posted them on social media.
The site attacked by the IAF is reportedly called "Tunis," and is used by the al-Qassam Brigades, the militant wing of Hamas, which governs the Gaza Strip.
Following the rocket attack on Thursday, which hit a yeshiva site in Sderot but did not explode, the city's mayor reportedly called for a land invasion of the self-governing Palestinian territory, according to YNet News.