Two bodies and 10 wounded people were taken to hospital following the blast, Reuters reported, citing health ministry spokesman Wahidullah Mayar.
"As a result of today's explosion in Kabul (Kota e Sangi- PD 5th), 10 injured and 2 martyrs have been evacuated to our hospitals," Wahidullah Mayar wrote on Twitter.
Social media users shared photos allegedly taken at the site.
According to TOLOnews, citing eyewitnesses, two vehicles have caught fire following the explosion.
A group of students were waiting outside the university when the blast happened, TOLOnews reported.
In June three separate blasts hit Kabul, leaving at least two people dead and 24 more injured.
No militant group claimed responsibility for the attack at the time, but both the Taliban radical movement and the Daesh terror organisation have recently stepped up their attacks in the country.
* Taliban and Daesh (Islamic State/ISIS/IS/ISIL) are terrorist groups banned in Russia and many other countries.