The fire began on Wednesday, according to the France Bleu radio station. It is now spreading toward the communes of Pradelles-en-Val and Montlaur 18 kilometers (11 miles) southeast of Carcassonne.
Over 500 firefighters and five aircraft have reportedly been mobilised to extinguish the fire.
The mayor of Pradelles-en-Val told the radio station that 22 people had been evacuated.