After the blast, a large number of security personnel and several teams of paramedics arrived at the scene.
The armoured riot police vehicles as well as the surrounding vehicles were damaged by the explosion.
There is no immediate information on casualties, according to the Ihlas news agency.
Adana Governor Mahmut Demirtas said that several police and civilians were wounded in the attack.
"Several policemen were injured in a bus explosion using an improvised explosive device in the Yuregir region, they were taken to hospitals", Demirtas was quoted as saying by the NTV broadcaster.
However, he added that the condition of the injured was not critical.