According to the outage map provided by the service, the connection problems have struck users from Europe, Eastern and Western coasts of the US.
Those users, who still have access to Twitter, have taken to the network to complain about the Instagram and Facebook application being down.
Following reports of access problems, a Facebook spokesperson confirmed to CTV News Vancouver that the company knew of the problem.
"We're aware that some people are currently having trouble accessing Facebook's family of apps," he said.
"We're working to get things back to normal as quickly as possible."