The San Antonio police chief shared preliminary information on the incident, saying the police received a call that shots were heard at a club around 8 p.m. local time, where "some type of concert" was taking place. Following an altercation between several individuals, "one person pulled out a gun and started shooting".
"Seven people were shot, two dead, five at local hospitals", McManus said.
Earlier, local media reported that the shooting had occurred inside a venue along San Antonio's Museum Reach portion of its River Walk.
One victim died at the venue, six others were transported to the hospital, where one person died shortly after, according to the report.
The victims have not been identified.
No further details were immediately available.