"Representatives of the armed forces intercepted an Embraer SENECA II aircraft with 430 packages of cocaine (a total of 482.520 kilograms). Two crew members from Brazil were detained," the ministry wrote on Twitter.
The anti-drug operation was carried out on Tuesday in the state of Lara, located in northwestern Venezuela.
According to the Venezuelan national anti-drug office, nearly 2.5 tonnes of illegal substances have been seized in Venezuela since the beginning of the year.