The plane, carrying high-level US and Israeli delegations, has taken off from Ben Gurion International Airport and will pass through the Saudi airspace to reach the UAE capital.
The US delegation is headed by Senior Presidential Adviser Jared Kushner and National Security Adviser Robert O’Brien. The Israeli delegation is chaired by the National Security Council head, Meir Ben Shabat, and consists of representatives of investment, civil aviation, foreign affairs, tourism and culture sectors.
"Our goal is to set a work plan to further develop and strengthen relations [with the UAE] in the tourism, innovation, economic and other fields," Ben Shabat told reporters ahead of the flight, which would take more than three hours.
The joint visit of the US-Israeli delegations to Abu Dhabi will last for two days.
In mid-August, Israel and the UAE struck a US-brokered deal to establish full diplomatic ties and exchange embassies in return for Israel putting the annexation of Palestinian lands on hold. The Palestinian Authority condemned the move as an act of betrayal.
After the deal was signed, UAE President Khalifa bin Zayed Al Nahyan on Saturday issued a decree on abolishing the economic boycott of Israel and related penalties.