Chinese Central Television reported that a gas explosion was the cause of the incident.
It is unclear whether the blast has claimed any lives, but at least three people were reported to have been injured.
According to local media reports, rescuers pulled many victims from under the rubble, but a search and rescue operation is still underway.
Social media users shared videos that showed the moment of the explosion that allegedly took place at the Zhuhai Baitengtou Tenghu Hotel.