"Seven carriages derailed and three cisterns spilled phosphoric acid. A crew of 44 firefighters is at the site struggling to stop the leakage," a statement read.
The truck was pulling a boat when it got wedged between the rails on a stretch between the towns of Rumigny and Liart and was hit by a cargo train.
The train driver was the only one hurt in the accident, according to the prefecture. Traffic on the route has been suspended until further notice and trains have been rerouted.