The bridge fell onto three lanes of the roadway and is trapping a truck.
D.C. Fire and EMS took to Twitter to provide some details on the accident.
A video from the scene of the collapse emerged online.
The bridge connected Polk Street NE to the western side of Kenilworth Avenue NW near Douglas Street NE. The traffic was suspended, the Metropolitan Area Transportation Operations Coordination said, as quoted by NBC.
Twitter users have been sharing photos from the area.