A small clump of nerve cells in the brain controls whether an individual continues to supply themselves with alcohol despite facing negative consequences, a new Swedish study has suggested.
Having initially studied rats, researchers at Linköping University have identified a previously unknown function in the brain that appears to control compulsory alcohol consumption.
With alcohol, only a small minority of those consuming it actually become addicted, and researchers may have struck paydirt as to why.
"We found that a small group of nerve cells in a small area of the brain makes the difference whether the individual is able to apply the brake in the normal way, which the majority of our rats do, or if the individual doesn't manage to stop", Markus Heilig, a professor at Linköping University, told the scientific website Forskning.se.
While a network of nerve cells with several centres in the brain has been found, its hub appears to be in the central amygdala. The amygdala is the centre of the brain that controls fear responses and is involved in learning behaviour linked to fear.
"I had not imagined that such a limited group of nerve cells could be so crucial for such a complex behaviour. And I couldn't imagine that it would be possible to show so distinctly, by manipulating these cells from the outside, that they are the ones causing the behaviour", Markus Heilig said.
To identify the molecular mechanisms behind compulsive alcohol consumption, the researchers began by singling out a vulnerable minority. In the study, the rats were taught that they can press a lever to receive a small amount of an alcohol solution. After a while, the conditions of the experiment changed, so that they received a shock together with the alcohol if they pressed the lever. Most of the rats then stopped with the on-demand alcohol. But in about a third, the brake did not work and they continued to self-administer alcohol despite the obvious discomfort.
In case of addiction development, one chooses alcohol over natural rewards despite possible consequences. An individual continues to drink even though they are aware that they will get sick and may eventually die. This process appears to be steered neurally by a group of nerve cells that control reward-seeking behaviour.
Early detection of risk groups can make it possible to work more proactively.
"In people with an increased risk of developing addiction, we need to strengthen the ability to slow down alcohol-seeking behaviour, both by training behaviour and by developing drugs", Markus Heilig concluded.