"We are closely monitoring events in Jerusalem during this sacred holiday period for Jews, Muslims and Christians. We urge everyone to avoid actions that further escalate tensions,’ the US embassy said in a statement.
Earlier on Friday, local media reported that more than 150 Palestinians were injured during clashes with Israeli police at the Al-Aqsa Mosque in Jerusalem. The police raided the mosque, which is the third holiest site in Islam, and used rubber bullets, noise bombs and tear gas to control the crowd.
The US embassy urged all parties to work jointly to ensure the enjoyment of religious holidays.
"We encourage all parties to work together to ensure calm and the quiet enjoyment of all religious holidays," the statement said.
In the past several weeks, the security situation in Israel has deteriorated, including four terror attacks that resulted in the killing of 14 people.