The accident occurred overnight, from Friday to Saturday, in the Naro-Fominsky district.
"A truck crashed into six cars that stopped at a traffic light. Four people died, two of them were children," the representative said.
The spokesperson added that two other people were injured in the accident.
Regional authorities said that one of the injured was taken to a hospital.
The prosecutor’s office of the Moscow region said on Telegram that the two children who died in the accident were aged ten and seven.