Air raid sirens went off in the Ukrainian region of Kiev, including the capital city itself, at around 23:35 local time on Sunday (20:35 GMT), the ministry’s online map showed.
Earlier in the evening, air raid alerts were issued in the Ukrainian regions of Kirovohrad, Chernihiv, Vinnytsia and Poltava.
Earlier on Sunday, air raid sirens sounded in the regions of Odessa, Mykolaiv, Dnipropetrovsk and the Ukraine-controlled part of Kherson region.
Ukrainian media reported that explosions were heard in Odessa and the Kiev region late on Sunday night.
Precision strikes against Ukrainian infrastructure have been carried out by Russia since October 10 (two days after the terrorist attack on the Crimean Bridge).
In February, the head of Ukrainian power grid operator Ukrenergo said that direct damage to Ukraine's energy infrastructure caused by Russian strikes may amount to hundreds of millions of dollars, with economic losses ranging in billions.