The NTSB's Office of Marine Safety, in conjunction with the Coast Guard, will attempt to find the potential cause of the deep-sea catastrophe, media said, though the US Coast Guard will lead the investigation, which has been called a major marine casualty.
The Canadian government also launched its own investigation into the incident on Friday, as Titan's support vessel was the Canadian-flagged Polar Prince.
On Sunday, the OceanGate submersible, Titan, went missing during an expedition to the Titanic wreckage in an area about 900 miles east of Cape Cod in the North Atlantic, at a depth of approximately 13,000 feet.