"On the night of September 20-21, an attempt by the Kiev regime to carry out a terrorist attack using aircraft-type unmanned aerial vehicles against facilities on the territory of the Russian Federation was thwarted," the ministry said in a statement.
"Air defense systems destroyed 19 Ukrainian UAVs over the waters of the Black Sea and the territory of the Republic of Crimea."
The ministry added that air defenses also destroyed three drones in Russia's other regions, "one each over the territories of the Kursk, Belgorod and Oryol regions."
Sevastopol Governor Mikhail Razvozhaev said on Telegram that all services were on alert in the city, adding that the air situation was monitored.
Andrei Klychkov, the governor of the Oryol region, has remarked that two drones that attempted to strike fuel and energy sector facilities had been neutralized. It was further stated that the attack did not cause any casualties or damages.