Washington has issued fresh Syria-related sanctions targeting 13 enterprises and 3 individuals, according to the US Treasury's website.
Samer Foz was designated along with Husen Foz, Amer Foz and 13 businesses in Syria, the United Arab Emirates and Lebanon, the Treasury said in a notice.
"Samer Foz, his relatives, and his business empire have leveraged the atrocities of the Syrian conflict into a profit-generating enterprise," Undersecretary for Terrorism and Financial Intelligence Sigal Mandelker said in the release.
Syria has been in a state of civil war since 2011, with forces backing the country's leader, President Assad, fighting numerous opposition groups backed by Western states, as well as militants and terrorist organisations.
The United States and its allies have been conducting military operations in Syria and neighbouring Iraq since 2014. The actions of the US-led coalition actions in Syria have never been authorised by Damascus or the UN Security Council.