Confidence in the current government was expressed by 151 lawmakers out of 299 who took part in the vote.
Opening the debates ahead of the vote, Tsipras asked the lawmakers to support his Cabinet and allow him to finalize important reforms by the end of his four-year term.
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Meanwhile, the opposition insisted that the current government should resign over its inability to resolve key problems in the country.
Previously, Tsipras called for a vote of confidence for his government, after ANEL — one of the ruling coalition parties — left the government. ANEL's move was the result of a clash of opinions on the issue of Macedonia changing its name to the Republic of North Macedonia.