The Syrian Air Defences responded to "hostile targets" in the airspace of Hama province, a SANA correspondent said on late Tuesday.
Several missiles launched from the air defences hit a number of enemy targets, the agency said later.
Supposed footage from the scene has been shared on social media.
It is at least the third attack on Syria's airspace this week, following air attacks in the provinces of As-Suwayda and Deir ez-Zor several hours ago, which killed two servicemen and left four others wounded. The source of the attack and the type of targets were not reported.
Earlier on Monday, Russian and Syrian air defence systems shot down two drones of militants near Hmeimim airbase, the Russian military said.