President Vladimir Putin submitted Luzhkov's candidacy to the legislature on Friday. The incumbent, whose position is formally equal to that of a regional governor, was first appointed mayor in 1992 by President Boris Yeltsin and won three re-elections until Putin scrapped elections of governors in 2005.
Speaking on his plans for his next term as mayor, Luzhkov said Saturday he would focus on housing construction, social support for the city's population, transport development and healthcare.
"We have a three-year plan to serve as a basis for the city's sustainable development," Luzhkov said. "At a meeting of the Moscow City Duma (legislature) on Wednesday I will make a report on the goals I intend to propose to Muscovites as mayor."
The Moscow legislature has 35 members, including 28 pro-presidential United Russia members.
"There can be no doubt that Luzhkov's candidacy will be approved," said Andrei Metelsky, deputy speaker of the house and the head of its United Russia faction.
Luzhkov, who has been repeatedly accused of corruption but has also overseen an economic boom in Moscow since the late nineties, was reportedly considering resigning later this year, but recently sent a formal request to Putin asking for re-nomination.