A Mercedes bus with 46 passengers crashed into a Kamaz truck in the southern Kyzylorda Region during the morning. The drivers of the vehicles and seven passengers died. Two bodies have yet to be identified.
The injured are being treated in hospital in Kyzylorda.
The accident is the seventh major road crash in Kazakhstan in the past two months, most of which have occurred in the country's south. A total of 19 people were killed and about 100 injured in the previous five accidents.
On October, 24, six people were killed and 14 injured when a VAZ car collided with a bus on the Almaty-Taraz highway in the south of the Central Asian country.
Three days earlier, 12 people died after a truck smashed into a public minibus on the highway between Almaty and Ust Kamenogorosk in the east of the country.