The main directions of reforms include establishing a new system to manage the civil service, introducing effective technology and modern methods of human resources operations, increasing the efficiency and professionalism of civil servants.
The decree will come into force from the day of its official publication.
The Russian prosecutor general said in February that some 3,700 corruption-related criminal cases had been opened in Russia during 2008.
Medvedev made the fight against corruption one of his top priorities soon after his inauguration last May, signing a decree just two weeks after he was sworn in to set up a presidential anti-corruption council.
He approved a plan to counter the problem in July 2008, proposing that special units be created in every branch of government. In line with the plan, Russian military officers, customs officials, judges and police would also have to declare their property.