Medvedev, described as Russian energy giant Gazprom's "link to the outside world," is listed among the Builders and Titans category, which also includes U.S. Treasury Secretary Timothy Geithner and designer Stella McCartney.
"One-third of the gas consumed in Europe passes through Medvedev's hands, and 60% of Gazprom's total revenues come from exports," said the magazine, whose list last year included Prime Minister Vladimir Putin.
At 53, Medvedev, the magazine said, "Believes in a bright future for natural gas and looks beyond the present crisis to the day when Gazprom's capitalization will shoot to a trillion dollars. Last summer it stood at a mere third of that amount."
Medvedev was a central figure in the gas transit row earlier this year between Gazprom and Ukraine which resulted in gas being cut off to Europe.
The list also includes German Chancellor Angela Merkel, U.S. President Barack Obama and British Prime Minister Gordon Brown along with actors Kate Winslet, Penelope Cruz, Brad Pitt and George Clooney.