Clinton will hold talks with her Armenian counterpart on Monday to try and find a settlement to the long-running Nagorny Karabakh conflict and following a Swiss-mediated agreement on a "roadmap" between Yerevan and Turkey.
Armenia and Turkey reached an agreement April 23 on a "roadmap" aimed at normalizing bilateral relations, which have been virtually non-existent following a bitter row over the massacre of ethnic Armenians in Turkey in the early 20th century.
Clinton will also meet with Azerbaijani Foreign Minister Elmar Mammadyarov on Tuesday prior to talks between the Armenian and Azerbaijani leaders in Prague on May 7.
Earlier U.S. Deputy Assistant Secretary of State for European and Eurasian Affairs Mathew Bryza said that a resolution on Nagorny Karabakh was "possible in the next few months."
The border between Armenia and Turkey was closed in 1993 on Ankara's initiative following fighting between Armenia and Turkey's ally, Azerbaijan, over Nagorny Karabakh.
The disputed region has a majority Armenian population, but which is within Azerbaijan's borders, declared its independence form Azerbaijan in late 1991 and has been a source of conflict ever since.
Turkey has said it wants talks with Armenia to take place in parallel to Armenian-Azerbaijani discussions on the future status of the region.