"I don't want to make you feel guilty, but I would like you to think just for a few minutes about what you could do to help," Pooley is expected to say, according to the BBC News. "This is a global problem and it will take the world to fix it. What a wonderful Christmas present that would be."
Pooley, a 29-year-old British nurse who contracted the disease while fighting to contain it in West Africa, will deliver the message from Sierra Leone, where he returned after recovering from the Ebola virus.
Channel 4's Christmas message has been in place since 1993 as an alternative to the Queen's official address. Every year Channel 4 chooses a prominent figure to make a statement. Last year, the Christmas speech was delivered by whistleblower and former NSA contractor Edward Snowden. He called for an end to mass surveillance by intelligence agencies.
The current outbreak of the Ebola virus began in December 2013 in Guinea. In the first few months of 2014, the virus reached Liberia, Sierra Leone, Nigeria and Senegal. Cases of the Ebola virus have also been reported outside of West Africa.
The World Health Organization (WHO) estimates that as many as 7,373 people have died from the virus so far.