According to the newspaper, the protest, called United We Stand Silent March was racially diverse and was devoted to the victims of police brutality.
The participants marched all the way to the Gateway Arch monument, forcing police to enforce security of the landmark.
Commenting the silence march, one of the organizers, Bishop Derrick Robinson, said that people don't have to be always "vocal and loud" and that silence "can make a powerful statement."
The march dispersed peacefully with no participants arrested for breaking the law.
The protest came amid public outrage and protests against police brutality in the United States, ignited by a recent grand jury decision not to indict white police officer Darren Wilson, who in August shot dead an unarmed black teenager, Michael Brown, in Ferguson, St. Louis County.