"This dangerous deal, as it appears to be emerging, bears out all of our fears, and even more than that," Netanyahu said.
He also pointed to advances made by Iranian-allied forces in Yemen and other Arab countries, blaming the Islamic republic for allegedly trying to "conquer the entire Middle East" while moving toward obtaining nuclear weapons.
"The Iran-Lausanne-Yemen axis is very dangerous to humanity, and must be stopped," according to Netanyahu, whose country is widely believed to have nuclear weapons itself.
Netanyahu spoke as Tehran and the six world powers are working diligently to clinch a comprehensive agreement on the Iranian nuclear program ahead of the March 31 deadline in Lausanne, Switzerland.
The six world powers, also known as the P5+1 group, are seeking to ensure that Iran cannot develop nuclear weapons. Tehran, in turn, denies that its uranium enrichment is being used for the construction of nuclear weapons, and says that its nuclear program is purely peaceful.
As for Netanyahu's efforts to campaign against Iran's nuclear talks, they culminated in his March 3 address to US Congress.
Back then, the Israeli Prime Minister slammed Tehran's nuclear program as "boring and repetitive." He also warned President Barack Obama against negotiating a nuclear agreement with Iran that he said would be a "countdown to a potential nuclear nightmare" by a country that "will always be an enemy of America."