Syrian government forces are engaged in a fight against rebel groups, including the Free Syrian Army (FSA) and the ISIL.
The US soldiers, all members of the Special Forces, are to join their Turkish colleagues at a military base in the central Turkish province of Kirsehir, the Hurriyet Daily News reported, citing unidentified sources.
The training will start in 10 days and will be held in groups of 400, according to the newspaper's sources. Turkey's National Intelligence Organization (MİT) is currently recruiting Syrians to join the program, according to the newspaper.
A US-led international coalition of more than 60 countries are conducting airstrikes against the IS in Syria and Iraq.
According to UN estimates, the Syrian Civil War has claimed at least 220,000 lives since mass protests evolved into a fully fledged war in 2011.